Overall interest
- Identification of intrinsic neuronal mechanisms underlying neurite outgrowth and axonal regeneration induced by receptor tyrosine kinase stimulation
- Modulation of receptor tyrosine kinase trafficking in neurons and glial cells with particular reference to the FGF receptor
Interference with receptor tyrosine kinase trafficking
- to promote neurite outgrowth and regeneration
- to inhibit glial proliferation and tumor growth
Promoting axonal elongation
- by stimulation of receptor tyrosine kinase signaling pathways
- by down-regulation or blockade of proteins inhibiting axon growth
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