Overall interest
- Identification of intrinsic neuronal mechanisms underlying neurite outgrowth and axonal regeneration induced by receptor tyrosine kinase stimulation
- Modulation of receptor tyrosine kinases trafficking in neurons and glial cells with particular reference to the FGF receptor
Goal: Promoting axonal elongation
- by application of trophic factors
- by down-regulation or blockade of proteins inhibiting axon growth
Goal: Modulation of FGF receptor trafficking
- to promote neurite outgrowth
- to interfere with glial proliferation
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